By Eric T. Wong
This concise textual content presents a whole assessment of alternating electrical fields treatment -- often referred to as tumor treating fields -- for glioblastoma and different different types of reliable tumor malignancies. Readers are given a basic figuring out of this novel anti-cancer therapy modality through studying from scientific trial info in addition to the actual and telephone biology results on tumor cells whilst alternating electrical fields are utilized either in vitro and in vivo.
Chapters illustrate the physics at the back of electrical box propagation in area and different media. this is often by way of a evaluation of our present knowing of the electrical box results on dividing cells - together with the disruption of cytokinesis, right chromosome segregation and activation at the mobilephone floor chaperons that result in immunogenic cellphone demise. info from section III trials for the therapy of recurrent and newly clinically determined glioblastomas are integrated, in addition to a number of the ancillary post hoc analyses that have been played by means of a number of investigators. the rest of the bankruptcy covers different reliable tumor malignancies, together with non-small telephone lung melanoma, pancreatic melanoma and ovarian melanoma, as this remedy modality is being utilized to systemic malignancies.
Alternating electrical Fields treatment in Oncology bargains oncologists, neurologists, radiation oncologists, biomedical engineers, mobile biologists and mitosis researchers the basics wanted for medical practice.
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Additional resources for Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields
Sajo proportional and dependent on the tissue’s electric resistance (R) at a particular electric potential or voltage (V). The differences in resistance will vary according to the magnitude of the dielectric property of the tissue that the electric field traverses. It is possible to generalize Eq. 2 by replacing (1) the current, I, with the current density, J ; (2) the inverse of the electric resistance, R, with the tissue-dependent conductivity, σ; and (3) the electric potential with the electric field E (Eq.
The targets of these fields are proteins such as α/β tubulin and septin that have high dipole moments. In the patient, TTFields are applied on the scalp by two pairs of orthogonally positioned transducer arrays. Because the energy delivered by TTFields is relatively low, the electric field is spatially distorted by variations in the local conductivity and relative permittivity of tissues and fluid cavities within the brain. This is in contradistinction to ionizing radiation used in external beam radiation therapy, in which high-energy beams at the higher frequency end of the electromagnetic spectrum are delivered to tissues, which are amenable to dosimetry delineation of the tumor target.
Stupp R, Tallibert S, Kanner AA, et al. Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial. JAMA. 2015;314:2535–43. 5. Response patterns of recurrent glioblastomas treated with tumor-treating fields. Semin Oncol. 2014;41 Suppl 6:S14–24. Wong ET, Lok E, Swanson KD, et al. Response assessment of NovoTTF-100A versus best physician’s choice chemotherapy in recurrent glioblastoma. Cancer Med. 2015;4:383–91. 7. Kirson ED, Gurvich Z, Schneiderman R, et al.
Alternating Electric Fields Therapy in Oncology: A Practical Guide to Clinical Applications of Tumor Treating Fields by Eric T. Wong